Tamiflu Dosage
Generic name: oseltamivir
Drug class: Neuraminidase inhibitors
Recommended Adult Dosing
Dosage forms: CAP: 30 mg, 75 mg; SUSP: 6 mg per mL
Special Note
- [www.cdc.gov/flu]
- Info: >98% of currently circulating influenza virus in US is oseltamivir-susceptible
Influenza A and B (seasonal flu) tx, uncomplicated
- [75 mg PO bid x5 days]
- Start: w/in 48h of sx onset; Info: may consider incr. to 105 mg PO bid in pregnant pts; may consider incr. to 150 mg PO bid if hospitalized w/ severe dz or immunocompromised, incl. pregnant pts; may extend tx if immunocompromised
Influenza A and B (seasonal flu) prophylaxis
- [75 mg PO qd x7 days after last known exposure]
- Start: w/in 48h of exposure; Info: give for at least 14 days and x7 days after last known case for institutional setting outbreaks; consider pre-exposure prophylaxis if very high risk for complications and cannot receive influenza vaccine, start when influenza activity detected in community and continue for duration of influenza activity
Renal dosing
- [treatment]
- CrCl 31-60: 30 mg bid x5 days; CrCl 11-30: 30 mg qd x5 days; CrCl <10: avoid use
- HD: 30 mg x1 then 30 mg 3x/wk after dialysis x5 days; consider supplement if next maint. dose not due right after dialysis; PD: 30 mg x1; supplement not defined
- [prophylaxis]
- CrCl 31-60: 30 mg qd; CrCl 11-30: 30 mg q48h; CrCl <10: avoid use
- HD: 30 mg x1 then 30 mg after every other dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 30 mg x1 then 30 mg qwk; supplement not defined
Hepatic dosing
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
SRC: NLM .