Tabloid Dosage

Generic name: thioguanine
Drug class: Antimetabolites

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Special Note

[uses, dosing may vary]
Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

AML

[combo tx, induction tx]
Dose: 100 mg/m^2/dose PO q12h x8-21 days; Info: decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) deficiency
[monotherapy, induction and consolidation tx]
Dose: 2 mg/kg/dose PO qd; Info: may incr. dose to 3 mg/kg/dose PO qd after 4wk; decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) deficiency

*ALL, late intensification tx

[60 mg/m^2/dose PO qd on days 29-42 of 56-day cycle]
Info: decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) deficiency

Renal dosing

renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[not defined]

 

SRC: NLM .