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  • Generic Name: epinephrine injection
  • Brand Name: Symjepi
  • Drug Class: Alpha/Beta Agonists
Last updated on MDtodate: 10/12/2022


Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports and studies are listed below.

Common adverse reactions to systemically administered epinephrine include: anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism.

Cardiovascular Reactions

  • Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs
  • Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease
  • Angina may occur in patients with coronary artery disease
  • Rare cases of stress cardiomyopathy have been reported in patients treated with epinephrine.

Reactions From Accidental Injection And/Or Improper Technique

  • Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area
  • Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.
  • Injection into the buttock has resulted in cases of gas gangren

Skin And Soft Tissue Infections

  • Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection in the thigh



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