Sutent Dosage

Generic name: sunitinib
Drug classes: Multikinase inhibitors, VEGF/VEGFR inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  CAP: 12.5 mg, 25 mg, 37.5 mg, 50 mg

Gastrointestinal stromal tumor, previously treated

[50 mg PO qd on days 1-28 of 42-day cycle]
Info: for pts w/ dz progression on or intolerance to imatinib

Renal cell CA

[adjuvant tx]
Dose: 50 mg PO qd on days 1-28 of 42-day cycle; Info: for pts w/ high recurrence risk; give x9 cycles
[advanced dz]
Dose: 50 mg PO qd on days 1-28 of 42-day cycle

Pancreatic neuroendocrine tumors, unresectable locally advanced or metastatic

[37.5 mg PO qd]
Info: for pts w/ progressive, well-differentiated dz

Renal dosing

renal impairment: no adjustment
HD: no initial dose adjustment, consider incr. subsequent doses up to 2x usual dose; PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .