Suboxone Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: SL STRIP: 2 mg/0.5 mg, 4 mg/1 mg, 8 mg/2 mg, 12 mg/3 mg
Restricted Distribution in US
- [1-866-287-2728 or www.samhsa.gov/medication-assisted-treatment for more info]
- Info: providers must receive training prior to obtaining product
Special Note
- [prescribing info]
- Info: consider prescribing naloxone if risk of opioid overdose or accidental ingestion
- [formulation clarification]
- Info: not bioequivalent to other buprenorphine/naloxone products; comparable doses are:
- [Suboxone or generic 2 mg/0.5 mg SL strip or generic 2 mg/0.5 mg SL tab]
- Info: equivalent to Zubsolv 1.4 mg/0.36 mg SL tab
- [Suboxone or generic 4 mg/1 mg SL strip]
- Info: equivalent to Zubsolv 2.9 mg/0.71 mg SL tab
- [Suboxone or generic 8 mg/2 mg SL strip or generic 8 mg/2 mg SL tab]
- Info: equivalent to Zubsolv 5.7 mg/1.4 mg SL tab
- [Suboxone or generic 12 mg/3 mg SL strip]
- Info: equivalent to Zubsolv 8.6 mg/2.1 mg SL tab
Short-acting opioid dependence, induction tx
- [individualize dose SL qd x2 days]
- Start: 2 mg/0.5 mg-4 mg/1 mg SL x1, may incr. by 2 mg/0.5 mg-4 mg/1 mg q2h up to 8 mg/2 mg/day on day 1, then give up to 16 mg/4 mg SL qd on day 2; begin when moderate withdrawal sx present and >6h after last opioid use; Info: do not cut/chew/swallow strip
Opioid dependence, maintenance tx
- [4 mg/1 mg-24 mg/6 mg buccally/SL qd]
- Start: 12 mg/3 mg-16 mg/4 mg buccally/SL qd or dose on last day of induction tx, then may adjust by 2 mg/0.5 mg-4 mg/1 mg per day; Max: 24 mg/6 mg/day; Info: do not cut/chew/swallow strip; taper dose gradually to D/C
Renal dosing
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
Hepatic dosing
- [induction tx]
- mod-severe impairment: avoid use
- [maintenance tx]
- moderate impairment: caution advised; severe impairment: avoid use
Recommended Peds Dosing
- Dosage forms: SL STRIP: 2 mg/0.5 mg, 4 mg/1 mg, 8 mg/2 mg, 12 mg/3 mg
Restricted Distribution in US
- [1-866-287-2728 or www.samhsa.gov/medication-assisted-treatment for more info]
- Info: providers must receive training prior to obtaining product
Special Note
- [prescribing info]
- Info: consider prescribing naloxone if risk of opioid overdose or accidental ingestion
- [formulation clarification]
- Info: not bioequivalent to other buprenorphine/naloxone products; comparable doses are:
- [Suboxone or generic 2 mg/0.5 mg SL strip or generic 2 mg/0.5 mg SL tab]
- Info: equivalent to Zubsolv 1.4 mg/0.36 mg SL tab
- [Suboxone or generic 4 mg/1 mg SL strip]
- Info: equivalent to Zubsolv 2.9 mg/0.71 mg SL tab
- [Suboxone or generic 8 mg/2 mg SL strip or generic 8 mg/2 mg SL tab]
- Info: equivalent to Zubsolv 5.7 mg/1.4 mg SL tab
- [Suboxone or generic 12 mg/3 mg SL strip]
- Info: equivalent to Zubsolv 8.6 mg/2.1 mg SL tab
Short-acting opioid dependence, induction tx
- [16 yo and older]
- Dose: individualize dose SL qd x2 days; Start: 2 mg/0.5 mg-4 mg/1 mg SL x1, may incr. by 2 mg/0.5 mg-4 mg/1 mg q2h up to 8 mg/2 mg/day on day 1, then give up to 16 mg/4 mg SL qd on day 2; begin when moderate withdrawal sx present and >6h after last opioid use; Info: do not cut/chew/swallow strip
*Opioid dependence, maintenance tx
- [16 yo and older]
- Dose: 4 mg/1 mg-24 mg/6 mg buccally/SL qd; Start: 12 mg/3 mg-16 mg/4 mg buccally/SL qd or dose on last day of induction tx, then may adjust by 2 mg/0.5 mg-4 mg/1 mg per day; Max: 24 mg/6 mg/day; Info: do not cut/chew/swallow strip; taper dose gradually to D/C
Renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
Hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance
SRC: NLM .