Strontium-89

Generic name: Strontium-89
Brand name: Metastron
Drug class: Therapeutic radiopharmaceuticals

Medically reviewed by  A Ras MD.

What is strontium-89 used for?

Strontium-89 is a prescription medicine that is used to treat bone pain caused by cancer.

Description

STRONTIUM CHLORIDE Sr-89 INJECTION, USP is a sterile, non-pyrogenic, aqueous solution of Strontium-89 Chloride for intravenous administration. The solution contains no preservative. Each milliliter contains:

Strontium Chloride 10.9 – 22.6 mg
Water for Injection q.s. to 1 mL

The radioactive concentration is 37 MBq/mL, 1 mCi/mL, and the specific activity is 2.96-6.17 MBq/mg, 80-167 µCi/mg at calibration. The pH of the solution is 4 – 7.5.

PHYSICAL CHARACTERISTIC

Strontium-89 decays by beta emission with a physical half-life of 50.5 days. The maximum beta energy is 1.463 MeV (100%). The maximum range of ß- particles from Strontium-89 in tissue is approximately 8 mm.

Radioactive decay factors to be applied to the stated value for radioactive concentration at calibration, when calculating injection volumes at the time of administration, are given in Table 1.

Table 1: Decay of Strontium-89

Day* Factor Day* Factor

-24

1.39

+6

0.92

-22

1.35

+8

0.90

-20

1.32

+10

0.87

-18

1.28

+12

0.85

-16

1.25

+14

0.83

-14

1.21

+16

0.80

-12

1.18

+18

0.78

-10

1.15

+20

0.76

-8

1.12

+22

0.74

-6

1.09

+24

0.72

-4

1.06

+26

0.70

-2

1.03

+28

0.68

0=calibration

1.00

* Days before (-) or after (+) the calibration date stated on the vial.

Before taking strontium-89, tell your doctor:

  • If you are allergic to strontium-89; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are breast-feeding. Do not breast-feed while you take strontium-89.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take strontium-89 with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take strontium-89?

  • Tell all of your health care providers that you take strontium-89. This includes your doctors, nurses, pharmacists, and dentists.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine is radioactive. You will need to follow what the doctor has told you to lessen being exposed to strontium-89.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking strontium-89, call your doctor right away.
  • Use birth control that you can trust to prevent pregnancy while taking strontium-89.

How is strontium-89 best taken?

Use strontium-89 as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a vein.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are the side effects of strontium-89 that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Feeling very tired or weak.

What are some other side effects of strontium-89?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Flushing.
  • More bone pain may rarely happen. Mild pain drugs may help. Call the doctor if this does not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out strontium-89?

If you need to store strontium-89 at home, talk with your doctor, nurse, or pharmacist about how to store it.

 

Label

Vial Label

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Outer Container Label

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SRC: NLM .

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