Soliris Dosage

Generic name: eculizumab
Drug class: Selective immunosuppressants

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Restricted Distribution in US

[1-888-765-4747 or www.solirisrems.com for more info]

Paroxysmal nocturnal hemoglobinuria

[900 mg IV q2wk]

Start: 600 mg IV qwk x4wk, then 900 mg IV qwk x1wk, then 900 mg IV q2wk; Info: give meningococcal vaccine >2wk before tx if unvaccinated, or give 2wk antibacterial prophylaxis if tx must start w/in 2wk of vaccination

Atypical hemolytic uremic syndrome

[1200 mg IV q2wk]

Start: 900 mg IV qwk x4wk, then 1200 mg IV qwk x1wk, then 1200 mg IV q2wk; Info: give meningococcal vaccine >2wk before tx if unvaccinated, or give 2wk antibacterial prophylaxis if tx must start w/in 2wk of vaccination; see pkg insert for supplemental dose if plasmapheresis, plasma exchange, or plasma infusion

Generalized myasthenia gravis

[1200 mg IV q2wk]

Start: 900 mg IV qwk x4wk, then 1200 mg IV qwk x1wk, then 1200 mg IV q2wk; Info: for anti-acetylcholine receptor antibody positive pts; give meningococcal vaccine >2wk before tx if unvaccinated, or give 2wk antibacterial prophylaxis if tx must start w/in 2wk of vaccination; see pkg insert for supplemental dose if plasmapheresis, plasma exchange, or plasma infusion

Neuromyelitis optica spectrum disorder

[1200 mg IV q2wk]

Start: 900 mg IV qwk x4wk, then 1200 mg IV qwk x1wk, then 1200 mg IV q2wk; Info: for anti-aquaporin-4 antibody positive pts; give meningococcal vaccine >2wk before tx if unvaccinated, or give 2wk antibacterial prophylaxis if tx must start w/in 2wk of vaccination; see pkg insert for supplemental dose if plasmapheresis, plasma exchange, or plasma infusion

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]

SRC: NLM .