Soliqua Dosage

Generic name: insulin glargine and lixisenatide
Drug class: Antidiabetic combinations

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ (SoloStar pen): 100 units/33 mcg per mL

Diabetes mellitus, type 2

[tx-naive pts]

Dose: 15-60 units SC qd; Start: 15 units SC qd, may adjust daily dose by 2-4 units no more frequently than qwk; Max: 60 units/day; Info: give <1h before 1st meal

[conversion from <30 units daily basal insulin or GLP-1 agonist]

Dose: 15-60 units SC qd; Start: D/C basal insulin or GLP-1 agonist, then start insulin glargine/lixisenatide 15 units SC qd, may adjust daily dose by 2-4 units no more frequently than qwk; Max: 60 units/day; Info: give <1h before 1st meal

[conversion from 30-60 units daily basal insulin]

Dose: 15-60 units SC qd; Start: D/C basal insulin w/ or w/o GLP-1 agonist, then start insulin glargine/lixisenatide 30 units SC qd, may adjust daily dose by 2-4 units no more frequently than qwk; Max: 60 units/day; Info: give <1h before 1st meal

Renal dosing

[see below]

eGFR >30: no adjustment; eGFR 15-29: not defined, caution advised; eGFR <15: avoid use

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .