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Slo-Niacin Dosage

Generic name: niacin (nicotinic acid)
Brand names: B-3-50, B3-500-Gr, Endur-acin, HDL Benefit.
Drug classes: Miscellaneous antihyperlipidemic agents, Vitamins

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  ER TAB: 250 mg, 500 mg, 750 mg

Special Note

[formulation clarification]
Info: not interchangeable w/ other niacin ER products; do not substitute on a mg to mg basis

Dietary supplementation

[1/2-1 tab PO qd]
Info: do not crush/chew tab; give w/ food; all available ER forms exceed normal upper limit for dietary reference intake; see Dietary Reference Intakes: Vitamin B3 (niacin) table

Hypercholesterolemia

[1000-2000 mg PO qhs]
Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

Mixed dyslipidemia

[1000-2000 mg PO qhs]
Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

Hypertriglyceridemia, type IV or V

[1000-2000 mg PO qhs]
Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

Cardiovascular event risk reduction

[1000-2000 mg PO qhs]
Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

CAD

[1000-2000 mg PO qhs]
Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: use w/ bile acid binding resin; aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

Renal dosing

renal impairment: not defined, caution advised
HD/PD: not defined

Hepatic dosing

hepatic dz hx: caution advised; unexplained elev. LFTs/active hepatic dz: contraindicated

 

SRC: NLM .

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