Slo-Niacin Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: ER TAB: 250 mg, 500 mg, 750 mg
Special Note
- [formulation clarification]
- Info: not interchangeable w/ other niacin ER products; do not substitute on a mg to mg basis
Dietary supplementation
- [1/2-1 tab PO qd]
- Info: do not crush/chew tab; give w/ food; all available ER forms exceed normal upper limit for dietary reference intake; see Dietary Reference Intakes: Vitamin B3 (niacin) table
Hypercholesterolemia
- [1000-2000 mg PO qhs]
- Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food
Mixed dyslipidemia
- [1000-2000 mg PO qhs]
- Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food
Hypertriglyceridemia, type IV or V
- [1000-2000 mg PO qhs]
- Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food
Cardiovascular event risk reduction
- [1000-2000 mg PO qhs]
- Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food
CAD
- [1000-2000 mg PO qhs]
- Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: use w/ bile acid binding resin; aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food
Renal dosing
- renal impairment: not defined, caution advised
- HD/PD: not defined
Hepatic dosing
- hepatic dz hx: caution advised; unexplained elev. LFTs/active hepatic dz: contraindicated
SRC: NLM .