Sinemet Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg
Parkinsonism
- [individualize dose PO tid-qid]
- Start: 10 mg/100 mg PO tid-qid or 25 mg/100 mg PO tid, may incr. by 1 tab/day q1-2 days; Max 200 mg/2000 mg/day; Info: 70-100 mg/day carbidopa needed to saturate periph. dopa decarboxylase and minimize adverse effects; taper dose gradually to D/C
Sleep-related eating disorder
- [25 mg/100 mg PO qhs]
*Restless legs syndrome
- [25 mg/100 mg PO qhs prn]
- Max: 50 mg/200 mg/day; Info: for intermittent sx; may start 12.5 mg/50 mg PO qhs x1-2 days; taper dose gradually to D/C
Renal dosing
- [adjust dose amount]
- CrCl <50: decr. usual dose by up to 50%
- HD: decr. usual dose by up to 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by up to 50%; no supplement
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
Recommended Peds Dosing
- Dosage forms: TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg
Dystonia, generalized
- [2 yo and older]
- Dose: individualize dose PO bid-tid; Start: 12.5 mg/50 mg PO bid, may incr. by 0.5-1 tab/day q3 days; Max: 20 mg/kg/day levodopa; Info: taper dose gradually to D/C
Renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
Hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance
SRC: NLM .