Sinemet Dosage

Generic name: carbidopa/levodopa

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg

Parkinsonism

[individualize dose PO tid-qid]
Start: 10 mg/100 mg PO tid-qid or 25 mg/100 mg PO tid, may incr. by 1 tab/day q1-2 days; Max 200 mg/2000 mg/day; Info: 70-100 mg/day carbidopa needed to saturate periph. dopa decarboxylase and minimize adverse effects; taper dose gradually to D/C

Sleep-related eating disorder

[25 mg/100 mg PO qhs]

*Restless legs syndrome

[25 mg/100 mg PO qhs prn]
Max: 50 mg/200 mg/day; Info: for intermittent sx; may start 12.5 mg/50 mg PO qhs x1-2 days; taper dose gradually to D/C

Renal dosing

[adjust dose amount]
CrCl <50: decr. usual dose by up to 50%
HD: decr. usual dose by up to 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by up to 50%; no supplement

Hepatic dosing

[not defined]
hepatic impairment: caution advised

 Recommended Peds Dosing

Dosage forms:  TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg

Dystonia, generalized

[2 yo and older]
Dose: individualize dose PO bid-tid; Start: 12.5 mg/50 mg PO bid, may incr. by 0.5-1 tab/day q3 days; Max: 20 mg/kg/day levodopa; Info: taper dose gradually to D/C

Renal dosing

[not defined]
renal impairment: consider adult renal dosing for guidance
HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[not defined]
hepatic impairment: consider adult hepatic dosing for guidance

SRC: NLM .