Siklos Dosage

Generic name: hydroxyurea
Brand names: Droxia, Hydrea, Mylocel, Siklos
Drug class: Antimetabolites

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 100 mg, 1000 mg

Sickle cell dz

[15-35 mg/kg/dose PO qd]
Start: 15 mg/kg/dose PO qd; Max: 35 mg/kg/day; Info: titrate by 5 mg/kg/day q8wk; may split tab; round dose to nearest 50 mg or 100 mg

Renal dosing

[adjust dose amount]
CrCl <60: decr. usual dose by 50%
HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement

Hepatic dosing

[not defined]
SRC: NLM .