Signifor LAR Dosage

Generic name: pasireotide
Brand names: Signifor, Signifor LAR
Drug class: Somatostatin and somatostatin analogs

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  INJ: 10 mg per 2 mL, 20 mg per 2 mL, 30 mg per 2 mL, 40 mg per 2 mL, 60 mg per 2 mL

Restricted Distribution in US

Acromegaly

[20-60 mg IM q4wk]
Start: 40 mg IM q4wk x3mo; Max: 60 mg/dose; 1 dose/4wk; Info: may adjust dose in 20 mg increments based on serum GH/IGF-1 levels and tx response

Cushing dz

[10-40 mg IM q4wk]
Start: 10 mg IM q4wk x4mo; Max: 40 mg/dose; 1 dose/4wk; Info: may adjust dose based on urinary free cortisol levels and tx response

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

[acromegaly]
Child-Pugh Class B: start 20 mg q4wk, max 40 mg/dose; Child-Pugh Class C: avoid use
[Cushing dz]
Child-Pugh Class B: start 10 mg q4wk, max 20 mg/dose; Child-Pugh Class C: avoid use

 

SRC: NLM .