Signifor LAR Dosage

Generic name: pasireotide
Brand names: Signifor, Signifor LAR
Drug class: Somatostatin and somatostatin analogs

Medically reviewed by A Ras MD.

Recommended Adult Dosing

Dosage forms: INJ: 10 mg per 2 mL, 20 mg per 2 mL, 30 mg per 2 mL, 40 mg per 2 mL, 60 mg per 2 mL

[20-60 mg IM q4wk]

Start: 40 mg IM q4wk x3mo; Max: 60 mg/dose; 1 dose/4wk; Info: may adjust dose in 20 mg increments based on serum GH/IGF-1 levels and tx response

[10-40 mg IM q4wk]

Start: 10 mg IM q4wk x4mo; Max: 40 mg/dose; 1 dose/4wk; Info: may adjust dose based on urinary free cortisol levels and tx response

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

[acromegaly]

Child-Pugh Class B: start 20 mg q4wk, max 40 mg/dose; Child-Pugh Class C: avoid use

[Cushing dz]

Child-Pugh Class B: start 10 mg q4wk, max 20 mg/dose; Child-Pugh Class C: avoid use

SRC: NLM .