Signifor Dosage

Generic name: pasireotide
Brand names: SigniforSignifor LAR
Drug class: Somatostatin and somatostatin analogs

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  INJ: 0.3 mg per mL, 0.6 mg per mL, 0.9 mg per mL

Restricted Distribution in US

Cushing dz

[0.3-0.9 mg SC bid]
Start: 0.6 mg or 0.9 mg SC bid; Info: adjust dose in 0.3 mg increments based on tx response and urinary free cortisol levels

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

Child-Pugh Class B: start 0.3 mg bid, max 1.2 mg/day; Child-Pugh Class C: avoid use

 

SRC: NLM .