Seroquel Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg
Schizophrenia
- [150-750 mg/day PO divided bid-tid]
- Start: 25 mg PO bid, then incr. by 50-150 mg/day up to 300-400 mg/day PO divided bid-tid by day 4, then may adjust dose by 50-100 mg/day no more frequently than q2 days prn; Max: 800 mg/day; Info: start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. WBC
Bipolar I disorder, manic
- [200-400 mg PO bid]
- Start: 50 mg PO bid, then incr. by 100 mg/day up to 200 mg PO bid by day 4, then may incr. by 200 mg/day prn; Max: 800 mg/day; Info: for acute monotherapy or acute or maint. lithium or valproate adjunct; start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. WBC
Bipolar disorder, acute depressive
- [300 mg PO qhs]
- Start: 50 mg PO qhs x1, then 100 mg PO qhs x1, then 200 mg PO qhs x1, then 300 mg PO qhs; Max: 300 mg/day; Info: start 50 mg PO qhs in elderly or debilitated pts, then incr. by 50 mg/day; D/C if ANC <1000; consider D/C if unexplained decr. WBC
Generalized anxiety disorder, tx-resistant
- [50-150 mg PO qd]
- Start: 25 mg PO qd, then incr. by 25-50 mg/day; Max: 300 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. WBC
Renal dosing
- renal impairment: no adjustment
- HD/PD: not defined
Hepatic dosing
- [adjust dose amount]
- hepatic impairment: start 25 mg qd, incr. 25-50 mg/day
SRC: NLM .