Segluromet Dosage

Generic name: ertugliflozin and metformin
Drug class: Antidiabetic combinations

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 2.5 mg/500 mg, 2.5 mg/1000 mg, 7.5 mg/500 mg, 7.5 mg/1000 mg

Diabetes mellitus, type 2

[conversion from metformin]

Dose: 1 tab PO bid; Start: ertugliflozin 2.5 mg PO bid plus current daily metformin dose PO divided bid; Max: 15 mg/2000 mg/day; Info: give w/ meals; hold tx for surgery if restricting food/fluid; consider holding tx at least 4 days before surgery; D/C for iodinated contrast study if eGFR <60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from ertugliflozin]

Dose: 1 tab PO bid; Start: current daily ertugliflozin dose PO divided bid plus metformin 500 mg PO bid; Max: 15 mg/2000 mg/day; Info: give w/ meals; hold tx for surgery if restricting food/fluid; consider holding tx at least 4 days before surgery; D/C for iodinated contrast study if eGFR <60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from ertugliflozin plus metformin]

Dose: 1 tab PO bid; Start: equivalent total daily dose of each component in current regimen PO divided bid; Max: 15 mg/2000 mg/day; Info: give w/ meals; hold tx for surgery if restricting food/fluid; consider holding tx at least 4 days before surgery; D/C for iodinated contrast study if eGFR <60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

Renal dosing

eGFR 30-44: avoid use; eGFR <30: contraindicated

HD/PD: contraindicated

Hepatic dosing

hepatic impairment: avoid use

SRC: NLM .