Sarclisa Dosage

Generic name: isatuximab-irfc
Drug class: CD38 monoclonal antibodies

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  INJ

Multiple myeloma, relapsed or refractory

[combo w/ pomalidomide and dexamethasone]
Dose: 10 mg/kg/dose IV x1 on days 1, 8, 15, and 22 of 28-day cycle for cycle 1, then 10 mg/kg/dose IV x1 on days 1, 15 of 28-day cycle starting cycle 2 until dz progression; Info: for pts who have received at least 2 prior tx, incl. lenalidomide and a proteasome inhibitor
[combo w/ carfilzomib and dexamethasone]
Dose: 10 mg/kg/dose IV x1 on days 1, 8, 15, and 22 of 28-day cycle for cycle 1, then 10 mg/kg/dose IV x1 on days 1, 15 of 28-day cycle starting cycle 2 until dz progression; Info: for pts who have received 1-3 prior tx

Renal dosing

renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined

 

SRC: NLM .