Samsca Dosage

Generic name: tolvaptan
Drug class: Vasopressin antagonists

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 15 mg, 30 mg

Hyponatremia, euvolemic

[15-60 mg PO qd]
Start: 15 mg PO qd, may incr. dose no more frequently than q24h to 30 mg PO qd, then to 60 mg PO qd; Max: 60 mg/day; 30 days; Info: avoid fluid restriction during first 24h of tx

Hyponatremia, hypervolemic

[15-60 mg PO qd]
Start: 15 mg PO qd, may incr. dose no more frequently than q24h to 30 mg PO qd, then to 60 mg PO qd; Max: 60 mg/day; 30 days; Info: avoid fluid restriction during first 24h of tx

Renal dosing

CrCl <10: avoid use; anuria: contraindicated
HD/PD: not defined

Hepatic dosing

hepatic dz: avoid use

 

SRC: NLM .