Rybrevant Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Adult Dosing
Dosage forms: INJ
Non-small cell lung CA, locally advanced or metastatic
- [<80 kg]
- Dose: 350 mg IV x1 on day 1 at wk 1, then 700 mg IV x1 on day 2 at wk 1, then 1050 mg IV qwk x3wk, then 1050 mg IV q2wk; Info: for pts w/ EGFR exon 20 insertion mutations w/ progressive dz on or after platinum-based chemo
- [>80 kg]
- Dose: 350 mg IV x1 on day 1 at wk 1, then 1050 mg IV x1 on day 2 at wk 1, then 1400 mg IV qwk x3wk, then 1400 mg IV q2wk; Info: for pts w/ EGFR exon 20 insertion mutations w/ progressive dz on or after platinum-based chemo
Renal dosing
- CrCl >29: no adjustment; CrCl <29: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin <1.5x ULN and any AST: no adjustment; bilirubin >1.5x ULN: not defined
SRC: NLM .