Rinvoq Dosage

Generic name: upadacitinib
Drug class: Antirheumatics

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  ER TAB: 15 mg, 30 mg, 45 mg

Rheumatoid arthritis, moderate-severe

[15 mg PO qd]
Info: see pkg insert for toxicity-related dose adjustments; do not cut/crush/chew tab

Psoriatic arthritis

[15 mg PO qd]
Info: see pkg insert for toxicity-related dose adjustments; do not cut/crush/chew tab

Ankylosing spondylitis

[15 mg PO qd]
Info: see pkg insert for toxicity-related dose adjustments; do not cut/crush/chew tab

Atopic dermatitis, moderate-severe refractory

[<65 yo]
Start: 15 mg PO qd; Info: may incr. to 30 mg PO qd if inadequate response; see pkg insert for toxicity-related dose adjustments; use lowest effective dose; do not cut/crush/chew tab; D/C if inadequate response w/ dose incr.
[65 yo and older]
Dose: 15 mg PO qd; Info: see pkg insert for toxicity-related dose adjustments; do not cut/crush/chew tab

Ulcerative colitis, moderate-severe

[induction tx]
Dose: 45 mg PO qd x8wk; Info: see pkg insert for toxicity-related dose adjustments; do not cut/crush/chew tab
[maintenance tx]
Dose: 15 mg PO qd; Info: may incr. to 30 mg PO qd for refractory, severe, or extensive dz; see pkg insert for toxicity-related dose adjustments; do not cut/crush/chew tab; D/C tx if inadequate response w/ dose incr.

Renal dosing

[ulcerative colitis induction tx]
eGFR 15-30: 30 mg qd; eGFR <15: avoid use
HD/PD: not defined
[atopic dermatitis or ulcerative colitis maintenance tx]
eGFR 15-30: 15 mg qd; eGFR <15: avoid use
HD/PD: not defined
[all other indications]
eGFR >15: no adjustment; eGFR <15: not defined
HD/PD: not defined

Hepatic dosing

[ulcerative colitis induction tx]
Child-Pugh Class A or B: 30 mg qd; Child-Pugh Class C: avoid use
[ulcerative colitis maintenance tx]
Child-Pugh Class A or B: 15 mg qd; Child-Pugh Class C: avoid use
[all other indications]
Child-Pugh Class C: avoid use

SRC: NLM .