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Rilpivirine Dosage

Generic name: rilpivirine
Brand name: Edurant
Drug class: NNRTIs

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg

HIV infection

[tx-naive]
Dose: 25 mg PO qd; Info: for pts w/ HIV-1 RNA <100,000 and CD4 >200; give w/ meals
[pregnant pts]
Dose: 25 mg PO qd; Info: for pts w/ HIV-1 RNA <50 on stable rilpivirine-containing regimen prior to pregnancy; give w/ meals
[lead-in dosing w/ PO cabotegravir]
Dose: 25 mg PO qd for at least 28 days; Start: 1mo before cabotegravir and rilpivirine injections; Info: for short-term tx in pts w/ HIV-1 RNA <50 and no known tx failure or resistance to cabotegravir or rilpivirine; give w/ meals
[replacement dosing for missed cabotegravir and rilpivirine injections]
Dose: 25 mg PO qd until next cabotegravir and rilpivirine injections for up to 2mo; Start: 1-2mo after last cabotegravir and rilpivirine injections; Info: for short-term tx if planned missed cabotegravir and rilpivirine injections by >7 days; give w/ PO cabotegravir; give w/ meals

HIV post-exposure prophylaxis

[25 mg PO qd]
Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; give w/ meals

Renal dosing

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised
HD/PD: not defined, caution advised

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .

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