Rilpivirine Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 25 mg
HIV infection
- [tx-naive]
- Dose: 25 mg PO qd; Info: for pts w/ HIV-1 RNA <100,000 and CD4 >200; give w/ meals
- [pregnant pts]
- Dose: 25 mg PO qd; Info: for pts w/ HIV-1 RNA <50 on stable rilpivirine-containing regimen prior to pregnancy; give w/ meals
- [lead-in dosing w/ PO cabotegravir]
- Dose: 25 mg PO qd for at least 28 days; Start: 1mo before cabotegravir and rilpivirine injections; Info: for short-term tx in pts w/ HIV-1 RNA <50 and no known tx failure or resistance to cabotegravir or rilpivirine; give w/ meals
- [replacement dosing for missed cabotegravir and rilpivirine injections]
- Dose: 25 mg PO qd until next cabotegravir and rilpivirine injections for up to 2mo; Start: 1-2mo after last cabotegravir and rilpivirine injections; Info: for short-term tx if planned missed cabotegravir and rilpivirine injections by >7 days; give w/ PO cabotegravir; give w/ meals
HIV post-exposure prophylaxis
- [25 mg PO qd]
- Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; give w/ meals
Renal dosing
- mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised
- HD/PD: not defined, caution advised
Hepatic dosing
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
SRC: NLM .