Rifapentine Dosage

Generic name: rifapentine
Brand name: Priftin
Drug class: Rifamycin derivatives

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 150 mg

Tuberculosis, active

[continuation phase, weekly regimen, non-HIV pts]
Dose: 10-20 mg/kg/dose PO qwk x18-31wk; Start: after completing initiation phase; Info: admin. by directly observed tx; give w/ isoniazid 900 mg PO qwk; not 1st-line tx; refer to ATS/CDC/IDSA guidelines; give w/ food
[*complete daily regimen, >40 kg]
Dose: 1200 mg PO qd x4mo; Info: for susceptible pulmonary infection; admin. by directly observed tx; give w/ moxifloxacin, isoniazid, and pyrazinamide for intensive phase x8wk; give w/ moxifloxacin and isoniazid for continuation phase to complete course; not 1st-line tx; refer to CDC guidelines; give w/ food

Tuberculosis, latent

[32.1-49.9 kg]
Dose: 750 mg PO qwk x3mo; Info: for non-pregnant pts; give w/ weekly isoniazid; 1st-line tx; give w/ food
[>50 kg]
Dose: 900 mg PO qwk x3mo; Info: for non-pregnant pts; give w/ weekly isoniazid; 1st-line tx; give w/ food
[*1 month daily regimen]
Dose: 600 mg PO qd x1mo; Info: for non-pregnant pts; not 1st-line tx; may self-admin; give w/ daily isoniazid; refer to WHO guidelines; give w/ food

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

hepatic impairment: caution advised

SRC: NLM .