Rifadin Dosage

Dosage forms:  CAP: 150 mg, 300 mg; INJ: various

Tuberculosis, active

[10 mg/kg/dose PO/IV qd for at least 6mo]

Max: 600 mg/dose; Alt: 10 mg/kg/dose PO/IV 2x, 3x, or 5x/wk for at least 6mo if directly observed tx, max 600 mg/dose; Info: part of multi-drug regimen; give on empty stomach; duration varies by infection site/severity

Tuberculosis, latent

[monotherapy]

Dose: 10 mg/kg/dose PO/IV qd x4mo; Max: 600 mg/day; Info: for HIV-negative pts; 1st-line tx; give on empty stomach

[*combo tx]

Dose: 10 mg/kg/dose PO/IV qd x3mo; Max: 600 mg/day; Info: give w/ isoniazid; 1st-line tx; give on empty stomach

Meningococcal prophylaxis

[600 mg PO bid x2 days]

Info: for asymptomatic meningococcal carriers; not for meningococcal infection tx; give on empty stomach

Endocarditis, staphylococcal prosthetic valve

[300 mg PO/IV q8h for at least 6wk]

Info: give w/ gentamicin gram positive synergy x2wk and nafcillin, cefazolin, or vancomycin; refer to AHA guidelines; give on empty stomach

Leprosy (Hansen dz), paucibacillary

[600 mg PO qmo x6mo]

Info: part of multi-drug regimen; give on empty stomach; consider 600 mg PO qd x6mo if unsupervised; may continue tx beyond 6mo in refractory cases

Leprosy (Hansen dz), multibacillary

[600 mg PO qmo x12mo]

Info: part of multi-drug regimen; give on empty stomach; consider 600 mg PO qd x12mo if unsupervised; may continue tx beyond 12mo in refractory cases

Anthrax, systemic

[600 mg IV q12h for at least 2wk]

Info: not 1st-line agent; part of multi-drug regimen; switch to PO abx for post-exposure prophylaxis if inhalational exposure

Brucellosis

[600 mg PO qd x6wk]

Info: part of multi-drug regimen

Renal dosing

[see below]

CrCl <50: decr. usual dose by 0-50%

HD: decr. usual dose by 0-50%; no supplement after dialysis; PD: decr. usual dose by 0-50%; no supplement

Hepatic dosing

hepatic impairment: avoid use; Info: use w/ caution if medically necessary