Reglan Dosage
Recommended Adult Dosing
Dosage Forms Discontinued in US
- [IM, IV not avail. as brand; see generic]
GERD
- [chronic sx]
- Dose: 10-15 mg PO/IM/IV qid; Max: 60 mg/day; 12wk; Info: start 5 mg PO/IM/IV qid in elderly pts; give 5mg PO/IM/IV qid or 10 mg PO/IM/IV tid, max 30 mg/day in poor CYP2D6 metabolizers; give 30min before meals if tid; give 30min before meals and before bedtime if qid
- [intermittent sx]
- Dose: up to 20 mg PO/IM/IV x1 before sx
Diabetic gastroparesis
- [10 mg PO/IM/IV qid]
- Max: 40 mg/day; 12wk; Info: start 5 mg PO/IM/IV qid in elderly pts; give 5mg PO/IM/IV qid, max 20 mg/day in poor CYP2D6 metabolizers; give 30min before meals and before bedtime if qid
Nausea/vomiting prevention, chemo-related
- [1-2 mg/kg/dose IV q2-3h]
- Info: give 30min before chemo, then repeat q2h x2 doses, then repeat q3h x3 doses; pretreat w/ diphenhydramine to decr. EPS; not 1st-line agent
Nausea/vomiting prevention, postop
- [10 mg IM/IV x1]
- Alt: 20 mg IM/IV x1; Info: give dose near end of procedure; may repeat q6-8h prn; not 1st-line agent
Small bowel intubation
- [10 mg IV x1 dose]
Radiologic exam
- [10 mg IV x1 dose]
*Nausea/vomiting, migraine-assoc.
- [10-20 mg IV x1]
- Alt: 5-10 mg PO/IM/IV q6-8h prn; Max: 45 mg/day
Renal dosing
- [GERD, chronic sx]
- CrCl <60: 5 mg qid or 10 mg tid, max 30 mg/day; ESRD: 5 mg qid or 10 mg bid, max 20 mg/day
- HD: 5 mg qid or 10 mg bid, max 20 mg/day; no supplement after dialysis; PD: 5 mg qid or 10 mg bid, max 20 mg/day; no supplement
- [diabetic gastroparesis]
- CrCl <60: 5 mg qid, max 20 mg/day; ESRD: 5 mg bid, max 10 mg/day
- HD: 5 mg bid, max 10 mg/day; no supplement after dialysis; PD: 5 mg bid, max 10 mg/day; no supplement
- [all other indications]
- CrCl 40-50: decr. usual dose by 25%; CrCl 10-39: decr. usual dose by 50%; CrCl <10: decr. usual dose by 75%
- HD: decr. usual dose by 75%; no supplement after dialysis; PD: decr. usual dose by 75%; no supplement
Hepatic dosing
- [GERD, chronic sx]
- Child-Pugh Class B or C: 5 mg qid or 10 mg tid, max 30 mg/day
- [diabetic gastroparesis]
- Child-Pugh Class B or C: 5 mg qid, max 20 mg/day
- [all other indications]
- hepatic impairment: no adjustment
Recommended Peds Dosing
- Dosage forms: TAB: 5 mg, 10 mg
Dosage Forms Discontinued in US
- [IM, IV not avail. as brand; see generic]
Small bowel intubation
- [<6 yo]
- Dose: 0.1 mg/kg/dose IV x1
- [6-14 yo]
- Dose: 2.5-5 mg IV x1
- [>14 yo]
- Dose: 10 mg IV x1
*GERD
- [0.1-0.2 mg/kg/dose PO/IM/IV qid]
- Max: 0.8 mg/kg/24h x12wk; Info: give 30min before meals and at bedtime if qid
*Nausea/vomiting prevention, chemo-related
- [1-2 mg/kg/dose IV q2-4h]
- Info: give 30min before chemo; pretreat w/ diphenhydramine to decr. EPS; not 1st-line agent
*Nausea/vomiting prevention, postop
- [0.1-0.2 mg/kg/dose IV x1]
- Info: give dose near end of procedure; may repeat q6-8h prn; not 1st-line agent
*Nausea/vomiting, migraine-assoc.
- [2 yo and older]
- Dose: 0.2 mg/kg/dose IV x1; Max: 10 mg/dose
Renal dosing
- [adjust dose amount]
- CrCl 40-50: decr. usual dose by 25%; CrCl 10-39: decr. usual dose by 50%; CrCl <10: decr. usual dose by 75%
- HD: decr. usual dose by 75%; no supplement after dialysis; PD: decr. usual dose by 75%; no supplement
Hepatic dosing
- [no adjustment]