Reblozyl Dosage

Generic name: luspatercept
Drug class: Miscellaneous erythropoiesis agents

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  INJ

Anemia

[transfusion-dependent beta thalassemia-assoc.]

Dose: 1-1.25 mg/kg/dose SC q3wk; Start: 1 mg/kg/dose SC q3wk, may incr. to 1.25 mg/kg/dose SC q3wk after at least 6wk of tx if no reduction in RBC transfusion burden; Max: 1.25 mg/kg/dose SC q3wk; Info: for pts requiring regular RBC transfusion; hold tx until Hgb <11 g/dL if pre-dose Hgb 11.5 g/dL or greater in absence of recent transfusion; see pkg insert for dose adjustments if Hgb incr. >2 g/dL w/ in 3wk of dose in absence of transfusion; D/C if no decr. in RBC transfusion burden after 9wk at max dose

[myelodysplastic syndrome w/ ring sideroblasts (MDS-RS)-assoc.]

Dose: 1-1.75 mg/kg/dose SC q3wk; Start: 1 mg/kg/dose SC q3wk, may incr. to 1.33 mg/kg/dose SC q3wk after at least 6wk of tx w/ 1 mg/kg dose if no reduction in RBC transfusion burden; may incr. to 1.75 mg/kg/dose SC q3wk after at least 6wk of tx w/ 1.33 mg/kg dose if no reduction in RBC transfusion burden; Max: 1.75 mg/kg/dose SC q3wk; Info: for pts w/ very low-intermediate risk dz who have failed ESA tx and requiring 2 or more RBC units over 8wk; hold tx until Hgb <11 g/dL if pre-dose Hgb 11.5 g/dL or greater in absence of recent transfusion; see pkg insert for dose adjustments if Hgb incr. >2 g/dL w/ in 3wk of dose in absence of transfusion; D/C if no decr. in RBC transfusion burden after 9wk at max dose

[myelodysplastic/myeloproliferative neoplasm w/ ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)-assoc.]

Dose: 1-1.75 mg/kg/dose SC q3wk; Start: 1 mg/kg/dose SC q3wk, may incr. to 1.33 mg/kg/dose SC q3wk after at least 6wk of tx w/ 1 mg/kg dose if no reduction in RBC transfusion burden; may incr. to 1.75 mg/kg/dose SC q3wk after at least 6wk of tx w/ 1.33 mg/kg dose if no reduction in RBC transfusion burden; Max: 1.75 mg/kg/dose SC q3wk; Info: for pts w/ very low-intermediate risk dz who have failed ESA tx and requiring 2 or more RBC units over 8wk; hold tx until Hgb <11 g/dL if pre-dose Hgb 11.5 g/dL or greater in absence of recent transfusion; see pkg insert for dose adjustments if Hgb incr. >2 g/dL w/ in 3wk of dose in absence of transfusion; D/C if no decr. in RBC transfusion burden after 9wk at max dose

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

AST/ALT >1-3x ULN and any bilirubin: no adjustment; AST/ALT >3x ULN and any bilirubin: not defined

SRC: NLM .