Pyrimethamine Dosage

Generic name: pyrimethamine
Brand name: Daraprim
Dosage form: oral tablet (25 mg)
Drug class: Miscellaneous antimalarials

Medically reviewed by  A Ras MD.

 

 Recommended Adult Dosing

Dosage forms:  TAB: 25 mg

Toxoplasmosis

[*prophylaxis, primary]
Dose: 50-75 mg PO qwk; Info: not 1st-line agent; give w/ dapsone, leucovorin
[treatment, <60 kg]
Dose: 200 mg PO x1, then 50 mg PO qd for at least 6wk; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin
[treatment, >60 kg]
Dose: 200 mg PO x1, then 75 mg PO qd for at least 6wk; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin
[*maintenance tx, <60 kg]
Dose: 25 mg PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin
[*maintenance tx, >60 kg]
Dose: 50 mg PO qd; Info: give w/ sulfadiazine and leucovorin or give w/ clindamycin and leucovorin

PCP prophylaxis

[50-75 mg PO qwk]
Info: not 1st-line agent; give w/ dapsone, leucovorin

Cystoisosporiasis

[acute infection treatment]
Dose: 50-75 mg PO qd; Info: not 1st-line agent; give w/ leucovorin
[chronic maintenance therapy]
Dose: 25 mg PO qd; Info: not 1st-line agent; give w/ leucovorin

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]
hepatic impairment: caution advised

SRC: NLM .