Prozac Dosage

Generic name: fluoxetine
Brand names: Prozac, Prozac Weekly
Drug class: Selective serotonin reuptake inhibitors

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  CAP: 10 mg, 20 mg, 40 mg

Major depressive disorder

[20-80 mg PO qam]
Start: 20 mg PO qam, may incr. dose after several wk; Max: 80 mg/day; Info: doses >20 mg/day may be divided bid; taper dose gradually to D/C

Major depressive disorder, tx-resistant

[20-50 mg PO qpm]
Start: 20 mg PO qpm; Max: 50 mg/day; Info: give w/ olanzapine; periodically reassess need for tx; taper dose gradually to D/C

Obsessive-compulsive disorder

[20-60 mg PO qam]
Start: 20 mg PO qam, may incr. dose after several wk; Max: 80 mg/day; Info: doses >20 mg/day may be divided bid; taper dose gradually to D/C

Bulimia nervosa

[60 mg PO qam]
Info: may titrate dose to 60 mg/day over several days; taper dose gradually to D/C

Panic disorder

[20 mg PO qam]
Start: 10 mg PO qam x1wk; Max: 60 mg/day; Info: taper dose gradually to D/C

Bipolar I disorder, acute depressive

[20-50 mg PO qpm]
Start: 20 mg PO qpm; Max: 50 mg/day; Info: give w/ olanzapine; periodically reassess need for tx; taper dose gradually to D/C

Cataplexy

[20-60 mg PO qam]
Start: 20 mg PO qam, may incr. dose qwk; Max: 80 mg/day; Info: doses >20 mg/day may be divided bid; taper dose gradually to D/C

Renal dosing

[no adjustment]
renal impairment: no adjustment
HD/PD: no adjustment; no supplement

Hepatic dosing

[adjust dose amount, frequency]
hepatic impairment: decr. dose or frequency, amount not defined
SRC: NLM .