Promacta Dosage

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 12.5 mg, 25 mg, 50 mg, 75 mg; SUSP: 12.5 mg per packet, 25 mg per packet

Chronic ITP

[50-75 mg PO qd]

Start: 50 mg PO qd; Max: 75 mg/day; Info: for pts w/ risk of bleeding who had insufficient response to corticosteroids, immunoglobulins, or splenectomy; give 1h before or 2h after meal; do not cut/crush/chew tab; use lowest effective dose to maintain Plt >50,000; see pkg insert for dose adjustments; D/C if no incr. in Plt after 4wk at max dose; start 25 mg PO qd in pts of East/Southeast Asian ancestry (risk of incr. drug levels)

Thrombocytopenia, chronic hepatitis C-assoc.

[25-100 mg PO qd]

Start: 25 mg PO qd; Max: 100 mg/day; Info: give 1h before or 2h after meal; do not cut/crush/chew tab; incr. dose q2wk to the lowest effective dose to maintain Plt necessary to initiate and maintain interferon-based antiviral tx; see pkg insert for dose adjustments; D/C when antiviral tx D/C

Aplastic anemia, severe

[first-line tx]

Dose: 150 mg PO qd x6mo; Max: 150 mg/day; Info: give 1h before or 2h after meal; do not cut/crush/chew tab; use w/ standard immunosuppressants; start 75 mg PO qd in pts of East/Southeast Asian ancestry (risk of incr. drug levels)

[refractory dz]

Dose: 50-150 mg PO qd; Start: 50 mg PO qd; Max: 150 mg/day; Info: give 1h before or 2h after meal; do not cut/crush/chew tab; incr. dose q2wk to the lowest effective dose to maintain hematologic response; see pkg insert for dose adjustments; D/C if no hematologic response after 16wk; start 25 mg PO qd in pts of East/Southeast Asian ancestry (risk of incr. drug levels)

Renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

[chronic ITP]

Child-Pugh Class A, B, or C: start 25 mg qd; start 12.5 mg qd in pts of East/Southeast Asian ancestry (risk of incr. drug levels); Info: may incr. dose no more frequently than q3wk

[thrombocytopenia, chronic hepatitis C-assoc.]

hepatic impairment: no adjustment

[aplastic anemia, first-line tx]

Child-Pugh Class A, B, or C: 75 mg qd; ALT or AST >6x ULN: avoid use

[aplastic anemia, refractory dz]

Child-Pugh Class A, B, or C: start 25 mg qd

SRC: NLM .