Prograf Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 0.5 mg, 1 mg, 5 mg; GRANULE: 0.2 mg per pkt, 1 mg per pkt; INJ: various
Heart transplant rejection prophylaxis
- [0.075 mg/kg/day PO divided q12h]
- Start: >6h post-transplant; Alt: 0.01 mg/kg/day IV infusion; Info: adjust dose based on serum levels
Liver transplant rejection prophylaxis
- [0.1-0.15 mg/kg/day PO divided q12h]
- Start: >6h post-transplant; Alt: 0.03-0.05 mg/kg/day IV infusion; Info: adjust dose based on serum levels
Kidney transplant rejection prophylaxis
- [0.1-0.2 mg/kg/day PO divided q12h]
- Start: w/in 24h post-transplant; delay if renal fxn not adequate; Alt: 0.03-0.05 mg/kg/day IV infusion; Info: adjust dose based on serum levels
Lung transplant rejection prophylaxis
- [0.075 mg/kg/day PO divided q12h]
- Start: >6h post-transplant; Alt: 0.01-0.03 mg/kg/day IV infusion; Info: adjust dose based on serum levels; pts w/ cystic fibrosis may require higher doses
Renal dosing
- [kidney transplant]
- renal impairment: give lowest recommended dose, may consider further dose decr.; postop oliguria: start 6-24h post-transplant; may delay until renal fxn adequate
- HD/PD: not defined
- [all other transplants]
- renal impairment: give lowest recommended dose, may consider further dose decr.
- HD/PD: not defined
Hepatic dosing
- hepatic impairment: give lowest recommended dose, may consider further dose decr.; Child-Pugh Score >10: decr. dose, amount not defined
SRC: NLM .