Prilosec Dosage

 Recommended Adult Dosing

Dosage forms:  DR GRANULE: 10 mg per pkt

GERD

[non-erosive, symptomatic]

Dose: 20 mg PO/NG qd x4-8wk; Info: give before meals; may open cap, see PPI Administration Alternatives table

[erosive esophagitis, short-term tx]

Dose: 20 mg PO/NG qd x4-12wk; Info: give before meals; may open cap, see PPI Administration Alternatives table

[erosive esophagitis, maintenance tx]

Dose: 20 mg PO/NG qd; Info: decr. dose to 10 mg PO/NG qd in Asian pts (incr. risk of CYP2C19 poor metabolizer); give before meals; may open cap, see PPI Administration Alternatives table

Gastric ulcer

[40 mg PO/NG qd x4-8wk]

Info: give before meals; may open cap, see PPI Administration Alternatives table

Duodenal ulcer

[20-40 mg PO/NG qd x4-8wk]

Info: maint. dose 20 mg/day; give before meals; may open cap, see PPI Administration Alternatives table

Hypersecretory conditions

[individualize dose PO/NG qd-tid]

Start: 60 mg PO/NG qd; Info: doses up to 120 mg PO tid have been used; divide doses >80 mg/day; give before meals; may open cap, see PPI Administration Alternatives table

H. pylori infection

[triple/quadruple tx]

Dose: 20 mg PO/NG bid x10-14 days; Info: part of multi-drug regimen, dosing may vary; search H. pylori Tx Regimens for guidelines; give omeprazole 20 mg PO/NG qd for additional 18 days if ulcer present; give before meals; may open cap, see PPI Administration Alternatives table

[dual tx]

Dose: 40 mg PO/NG qd w/ clarithromycin 500 mg PO tid x14 days; Info: not 1st-line tx, dosing may vary; search H. pylori Tx Regimens for guidelines; give omeprazole 20 mg PO/NG qd for additional 14 days if ulcer present; give before meals; may open cap, see PPI Administration Alternatives table

Gastric ulcer prophylaxis, NSAID-assoc.

[20-40 mg PO/NG qd]

Info: associated w/ NSAID use; give before meals; may open cap, see PPI Administration Alternatives table

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[erosive esophagitis, maintenance tx]

hepatic impairment: 10 mg qd

[all other indications]

hepatic impairment: not defined