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Prevymis Dosage

Generic name: letermovir (oral/injection)
Drug class: Miscellaneous antivirals

Medically reviewed by  A Ras MD.


 Recommended Adult Dosing

Dosage forms:  TAB: 240 mg, 480 mg; INJ: various

CMV prophylaxis, allogeneic HSCT

[480 mg PO/IV qd until 100 days post-transplant]
Start: between days 0 and 28 of transplant; Info: for CMV seropositive recipients; switch to PO form when possible

Renal dosing

[PO route]
CrCl >10: no adjustment; CrCl <10: not defined
HD/PD: not defined
[IV route]
CrCl >50: no adjustment; CrCl <50: not defined, caution advised; Info: PO route preferred due to accumulation of toxic IV vehicle
HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: avoid use


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