Premarin Cream Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg; INJ: various
Vasomotor sx, mod-severe menopausal
- [0.3-1.25 mg PO qd]
- Start: 0.3 mg PO qd; Alt: cycle 25 days on, 5 days off; Info: add progestin x10-14 days/cycle if intact uterus; use lowest effective estrogen dose, shortest effective tx duration
Vulvovaginal atrophy, menopausal
- [0.3-1.25 mg PO qd]
- Start: 0.3 mg PO qd; Alt: cycle 25 days on, 5 days off; Info: add progestin x10-14 days/cycle if intact uterus; use lowest effective estrogen dose, shortest effective tx duration; not preferred if local sx only
Osteoporosis prevention, postmenopausal
- [0.3-0.625 mg PO qd]
- Start: 0.3 mg PO qd; Alt: cycle 25 days on, 5 days off; Info: add progestin x10-14 days/cycle if intact uterus; weigh estrogen tx risk/benefit
Hypoestrogenism
- [assoc. w/ hypogonadism]
- Dose: 0.3-1.25 mg PO qd; Info: cycle 21 days on, 7 days off; titrate to lowest effective maint. dose; add progestin x10-14 days/cycle if intact uterus; reassess tx need q3-6mo
- [assoc. w/ oopherectomy or primary ovarian failure]
- Dose: 1.25 mg PO qd; Info: cycle 21 days on, 7 days off; add progestin x10-14 days/cycle if intact uterus; reassess tx need q3-6mo
Metastatic breast CA, palliative tx
- [10 mg PO tid for at least 3mo]
Advanced prostate CA, palliative tx
- [1.25-2.5 mg PO tid]
Dysfunctional uterine bleeding
- [25 mg IM/IV x1]
- Info: may repeat dose in 6-12h; IV route preferred over IM route
*Uremic bleeding
- [0.6 mg/kg/dose IV qd x5 days]
Renal dosing
- renal dz: not defined, caution advised
- HD/PD: not defined, caution advised
Hepatic dosing
- hepatic impairment: contraindicated
SRC: NLM .