Praluent Dosage

Generic name: alirocumab
Brand names: Praluent Pen, Praluent Syringe
Drug class: PCSK9 inhibitors

Recommended Adult Dosing

Dosage forms:  INJ (pen): 75 mg per mL, 150 mg per mL

Primary hyperlipidemia, adjunct tx

[75 mg SC q2wk]
Max: 150 mg q2wk; Alt: 300 mg SC q4wk; Info: may incr. dose to 150 mg SC q2wk after 4-8wk

Heterozygous familial hypercholesterolemia, adjunct tx

[75 mg SC q2wk]
Max: 150 mg q2wk; Alt: 300 mg SC q4wk; Info: may incr. dose to 150 mg SC q2wk after 4-8wk; give 150 mg SC q2wk if LDL apheresis

Homozygous familial hypercholesterolemia, adjunct tx

[150 mg SC q2wk]

Cardiovascular event risk reduction

[75 mg SC q2wk]
Max: 150 mg q2wk; Alt: 300 mg SC q4wk; Info: may incr. dose to 150 mg SC q2wk after 4-8wk

Renal dosing

mild-moderate impairment: no adjustment; severe impairment: not defined
HD/PD: not defined

Hepatic dosing

mild-moderate impairment: no adjustment; severe impairment: not defined
SRC: NLM .