Plegridy Dosage

Generic name: peginterferon beta-1a
Drug class: Interferons

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ (auto-injector starter pack, SC): 63 mcg and 94 mcg; INJ (auto-injector, SC): 125 mcg; INJ (pre-filled syringe starter pack, SC): 63 mcg per 0.5 mL and 94 mcg per 0.5 mL; INJ (pre-filled syringe, SC): 125 mcg per 0.5 mL; INJ (pre-filled syringe, IM): 125 mcg per 0.5 mL

Multiple sclerosis, relapsing forms

[SC route]
Dose: 125 mcg SC q14 days; Start: 63 mcg SC x1 on day 1, then 94 mcg SC x1 on day 15, then 125 mcg SC x1 on day 29, then 125 mcg SC q14 days; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz
[IM route]
Dose: 125 mcg IM q14 days; Start: 63 mcg IM x1 on day 1, then 94 mcg IM x1 on day 15, then 125 mcg IM x1 on day 29, then 125 mcg IM q14 days; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; use pre-filled IM syringe w/ titration devices to deliver start doses of 63 mcg, 94 mcg

Renal dosing

[see below]
mild-mod impairment: no adjustment; severe impairment: caution advised, monitor for adverse effects
HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .