Pirfenidone Dosage

Generic name: pirfenidone
Brand name: Esbriet
Drug class: Miscellaneous uncategorized agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 267 mg; TAB: 267 mg, 801 mg

Idiopathic pulmonary fibrosis

[801 mg PO tid]
Start: 267 mg PO tid x7 days, then 534 mg PO tid x7 days, then 801 mg PO tid; Max: 2403 mg/day; Info: see pkg insert for toxicity-related dose adjustments; retitrate from 267 mg PO tid if tx interrupted for >14 days; give w/ food

Renal dosing

CrCl <80: consider decr. usual dose
HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: monitor closely, consider decr. dose; Child-Pugh Class C: avoid use
SRC: NLM .