Pimozide Dosage

Generic name: pimozide
Brand name: Orap
Drug class: Miscellaneous antipsychotic agents

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 1 mg, 2 mg

Tourette syndrome, severe

[2-10 mg/day PO divided qd-bid]
Start: 1-2 mg/day PO divided qd-bid, may incr. dose qod; Max: 0.2 mg/kg/day up to 10 mg/day; Info: perform CYP2D6 genotyping if doses >4 mg/day; in poor CYP2D6 metabolizers, may incr. dose q14 days up to max 4 mg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Renal dosing

renal impairment: not defined, caution advised
HD/PD: not defined, caution advised

Hepatic dosing

[not defined]
hepatic impairment: caution advised

Recommended Peds Dosing

Dosage forms:  TAB: 1 mg, 2 mg

Tourette syndrome, severe

[12 yo and older]
Dose: 1-10 mg/day PO divided qd-bid; Start: 0.05 mg/kg/dose PO qhs, may incr. dose q3 days; Max: 0.2 mg/kg/day up to 10 mg/day; Info: perform CYP2D6 genotyping if doses >0.05 mg/kg/day; in poor CYP2D6 metabolizers, may incr. dose q14 days up to max 0.05 mg/kg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

Renal dosing

renal impairment: not defined, caution advised
HD/PD: not defined, caution advised

Hepatic dosing

[not defined]
hepatic impairment: caution advised

 

SRC: NLM .