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Pentobarbital Dosage

Generic name: pentobarbital (injection)
Brand names: Nembutal Sodium, Nembutal
Dosage form: injectable solution (50 mg/mL)
Drug class: Barbiturates

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Procedural sedation

[150-200 mg IM x1]
Info: onset 10-15min IM, duration 1-4h IM

Barbiturate coma

[1-3 mg/kg/h IV]
Start: 10-15 mg/kg/dose IV x1, then 1 mg/kg/h IV; Info: taper dose gradually to D/C if long-term use

Renal dosing

[adjust dose amount]
renal impairment: decr. usual dose, amount not defined
HD/PD: not defined

Hepatic dosing

[adjust dose amount]
hepatic impairment: decr. usual dose, amount not defined

Recommended Peds Dosing

Dosage forms:  INJ

Procedural sedation

[2-6 mg/kg/dose IM x1]
Max: 100 mg/dose; Alt: 1-3 mg/kg/dose IV x1; Info: onset 10-15min IM, 1min IV; duration 1-4h IM, 15min IV

Barbiturate coma

[1-3 mg/kg/h IV]
Start: 10-15 mg/kg/dose IV x1, then 1 mg/kg/h IV; Info: taper dose gradually to D/C if long-term use

Renal dosing

[adjust dose amount]
renal impairment: decr. usual dose, amount not defined
HD/PD: not defined

Hepatic dosing

[adjust dose amount]
hepatic impairment: decr. usual dose, amount not defined

SRC: NLM .

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