Pentam Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
PCP tx, mod-severe
- [4 mg/kg/dose IV/IM q24h x21 days]
- Info: not 1st-line agent; IV preferred to IM; may consider decr. dose to 3 mg/kg/dose IV/IM q24h if toxicities occur
PCP prophylaxis
- [300 mg NEB q4wk]
- Info: not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial w/ 6 mL sterile water; do not mix w/ other nebulized meds
Human African trypanosomiasis
- [4 mg/kg/dose IM/IV q24h x7 days]
- Info: for 1st stage dz caused by Trypanosoma brucei gambiense
Renal dosing
- [IV/IM route]
- CrCl 10-50: 3 mg/kg/dose IV/IM q24h; CrCl <10: 4 mg/kg/dose IV/IM q48h
- HD: 4 mg/kg/dose IV/IM q48h; no supplement after dialysis; PD: 4 mg/kg/dose IV/IM q48h; no supplement
- [NEB route]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised if IV/IM route
Recommended Peds Dosing
- Dosage forms: INJ
PCP tx
- [>4 mo]
- Dose: 4 mg/kg/dose IV/IM q24h x21 days; Info: not 1st-line agent; IV preferred to IM; may consider decr. dose to 3 mg/kg/dose IV/IM q24h if toxicities occur; may switch to PO regimen to complete course if improvement after 7-10 days
PCP prophylaxis
- [5 yo and older]
- Dose: 300 mg NEB q4wk; Info: not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial w/ 6 mL sterile water; do not mix w/ other nebulized meds
Human African trypanosomiasis
- [>4 mo]
- Dose: 4 mg/kg/dose IM/IV q24h x7 days; Info: for 1st stage dz caused by Trypanosoma brucei gambiense
Renal dosing
- [IV/IM route]
- CrCl 10-29: give usual dose IV/IM q36h; CrCl <10: give usual dose IV/IM q48h
- HD: give usual dose IV/IM q48h; no supplement after dialysis; PD: give usual dose IV/IM q48h; no supplement
- [NEB route]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised if IV/IM route
SRC: NLM .