Pemazyre Dosage
Generic name: pemigatinib
Drug class: Multikinase inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 4.5 mg, 9 mg, 13.5 mg
Restricted Distribution in US
- [1-855-452-5234 or www.pemazyre.com for more info]
Cholangiocarcinoma, unresectable locally advanced or metastatic
- [13.5 mg PO qd on days 1-14 of 21-day cycle]
- Info: for pts w/ previously treated dz w/ fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement; do not cut/crush/chew tab
Myeloid/lymphoid neoplasm, relapsed or refractory
- [13.5 mg PO qd]
- Info: for pts w/ fibroblast growth factor receptor 1 (FGFR1) rearrangement; do not cut/crush/chew tab
Renal dosing
- [cholangiocarcinoma, unresectable locally advanced or metastatic]
- eGFR 15-29: 9 mg qd on days 1-14 of 21-day cycle; eGFR <15: not defined
- HD: no adjustment; no supplement; PD: not defined
- [myeloid/lymphoid neoplasm, relapsed or refractory]
- eGFR 15-29: 9 mg qd; eGFR <15: not defined
- HD: no adjustment; no supplement; PD: not defined
Hepatic dosing
- [cholangiocarcinoma, unresectable locally advanced or metastatic]
- bilirubin 1.1-3x ULN and any AST: no adjustment; bilirubin >3x ULN and any AST: 9 mg qd on days 1-14 of 21-day cycle
- [myeloid/lymphoid neoplasm, relapsed or refractory]
- bilirubin 1.1-3x ULN and any AST: no adjustment; bilirubin >3x ULN and any AST: 9 mg qd
SRC: NLM .