Palynziq Dosage

Generic name: pegvaliase
Drug class: Miscellaneous metabolic agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ (pre-filled syringe): 2.5 mg per 0.5 mL, 10 mg per 0.5 mL, 20 mg per mL

Restricted Distribution in US

PKU

[20-60 mg SC qd]

Start: 2.5 mg SC qwk x4wk, then 2.5 mg SC 2x/wk x1wk, then 10 mg SC qwk x1wk, then 10 mg SC 2x/wk x1wk, then 10 mg SC 4x/wk x1wk, then 10 mg SC qd x1wk, then 20 mg SC qd x24wk, then may incr. to 40 mg SC qd x16wk; Max: 60 mg/day; Info: for pts w/ phenylalanine level >600 on existing tx; consider premed w/ antihistamine or antipyretic; may incr. dose to 60 mg SC qd if tolerated; D/C if inadequate response after 16wk tx on max dose

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .