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Palbociclib Dosage

Generic name: palbociclib
Brand name: Ibrance
Drug class: CDK 4/6 inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 75 mg, 100 mg, 125 mg; TAB: 75 mg, 100 mg, 125 mg

Hormone receptor-positive HER2-negative breast CA, advanced or metastatic

[initial tx]
Dose: 125 mg PO qd on days 1-21 of 28-day cycle; Info: for male and postmenopausal female pts; use w/ aromatase inhibitor; consider giving w/ LHRH agonist if used for male pts; give caps w/ food; do not open cap; do not cut/crush/chew tab
[progressive dz]
Dose: 125 mg PO qd on days 1-21 of 28-day cycle; Info: use w/ fulvestrant; give w/ LHRH agonist if used for pre/perimenopausal pts; give caps w/ food; do not open cap; do not cut/crush/chew tab

Renal dosing

[see below]
CrCl >15: no adjustment; CrCl <15: not defined
HD/PD: not defined

Hepatic dosing

[see below]
Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: 75 mg qd on days 1-21 of 28-day cycle

 

SRC: NLM .

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