Padcev Dosage

Generic name: enfortumab vedotin
Drug class: Miscellaneous antineoplastics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Urothelial carcinoma, locally advanced or metastatic

[1.25 mg/kg/dose IV x1 on days 1, 8, 15 of 28-day cycle]

Max: 125 mg/dose; Info: for pts previously treated w/ PD-1/PD-L1 inhibitor and platinum-containing chemo or cisplatin-ineligible pts who have received at least 1 prior tx

Renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[see below]

bilirubin 1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN or AST/ALT >2.5x ULN: avoid use

SRC: NLM .