Oxycontin Dosage

Generic name: oxycodone
Drug class: Narcotic analgesics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  ER TAB: 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Pain, severe chronic

[opioid-naive or opioid-nontolerant pts]

Dose: individualize dose PO q12h; Start: 10 mg PO q12h, may incr. total daily dose by 25-50% q1-2 days; Info: use lowest effective dose, shortest effective tx duration; titrate slowly in pts 65 yo and older; decr. start dose 50-66% in debilitated pts 65 yo and older and titrate w/ caution; >40 mg/dose, >80 mg/day for use in opioid-tolerant pts only; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use

[opioid-tolerant pts]

Dose: individualize dose PO q12h; Start: individualize start dose based on current opioid intake, see pkg insert for conversion; may incr. total daily dose by 25-50% q1-2 days; Info: use lowest effective dose, shortest effective tx duration; titrate slowly in pts 65 yo and older; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use

Renal dosing

[see below]

CrCl <60: titrate slowly

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

Hepatic impairment: decr. usual start dose 50-66%, titrate slowly

Recommended Peds Dosing

Dosage forms:  ER TAB: 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Pain, severe chronic

[opioid-tolerant pts, 11 yo and older]

Dose: individualize dose PO q12h; Start: individualize start dose based on current opioid intake, see pkg insert for conversion; may incr. total daily dose by 25% q1-2 days; Info: for use in pts receiving at least 20 mg oxycodone/day or equivalent for at least 2 days immed. before tx start; use lowest effective dose, shortest effective tx duration; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use

Renal dosing

[see below]

CrCl 10-50: decr. usual dose by 25%; CrCl <10: decr. usual dose by 50%

HD/PD: decr. usual dose by 50%; no supplement after dialysis

Hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual start dose 50-66%, titrate slowly