Oxacillin

Generic name: oxacillin (injection)
Brand names: Oxacillin Sodium ADD-Vantage, Bactocill
Dosage forms: injectable powder for injection (1 g; 10 g; 2 g); intravenous solution (1 g/50 mL; 2 g/50 mL)
Drug class: Penicillinase resistant penicillins

Medically reviewed by  A Ras MD.

What is oxacillin used for?

Oxacillin is a prescription medicine that is used to treat bacterial infections.

Description

Oxacillin for Injection, USP is a semisynthetic penicillin antibiotic derived from the penicillin nucleus, 6-amino-penicillanic acid.  It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). It is the sodium salt in parenteral dosage form for intramuscular or intravenous use.
Each vial of Oxacillin for Injection, USP contains oxacillin sodium monohydrate equivalent to 1 gram or 2 grams of oxacillin. The sodium content is 64 mg (2.8 mEq) per gram oxacillin. The product is buffered with 21 mg dibasic sodium phosphate per gram oxacillin. Oxacillin for Injection, USP is white to off white powder and gives a clear solution upon reconstitution.OxacillinOXACILLIN SODIUM

 

 

The chemical name of oxacillin sodium is 4-Thia-1-azabicyclo [3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl) carbonyl]-amino]-7-oxo-, monosodium salt, monohydrate, [2S(2α,5α,6β)]-. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase). The molecular formula of oxacillin sodium is C19H18N3NaO5S • H2O. The molecular weight is 441.44.

Before taking oxacillin, tell your doctor:

  • If you are allergic to oxacillin; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are taking tetracycline.

This is not a list of all drugs or health problems that interact with oxacillin.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take oxacillin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take oxacillin?

  • Tell all of your health care providers that you take oxacillin. This includes your doctors, nurses, pharmacists, and dentists.
  • Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor.
  • Have your blood work checked if you are on oxacillin for a long time. Talk with your doctor.
  • Do not use longer than you have been told. A second infection may happen.
  • If you are on a low-sodium or sodium-free diet, talk with your doctor. Some of these products have sodium.
  • Use with care in children. Talk with the doctor.
  • If you are 65 or older, use oxacillin with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using oxacillin while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is oxacillin best taken?

Use oxacillin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a muscle or as an infusion into a vein over a period of time.
  • It is given as a shot into a vein.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are the side effects of oxacillin that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Very bad dizziness or passing out.
  • Muscle or joint pain.
  • Mouth irritation.
  • Feeling very tired or weak.
  • Very bad belly pain.
  • Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.
  • Rarely, low blood cell counts have happened with oxacillin. Call your doctor right away if you have any unexplained bruising or bleeding; signs of infection like fever, chills, or sore throat; or feel very tired or weak.

What are some other side effects of oxacillin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Diarrhea.
  • Change in tongue color.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out oxacillin?

  • If you need to store oxacillin at home, talk with your doctor, nurse, or pharmacist about how to store it.

 

Label

PACKAGE LABEL- PRINCIPAL DISPLAY – Oxacillin 1 gram Carton Label

  •  NDC 63323-813-20
    Oxacillin
    for Injection, USP
    1 gram per vial
    Buffered-For Intramuscular or Intravenous use
    Rx only
    10 x 1 gram
    Single Dose Vials
1gramctn

 

PACKAGE LABEL- PRINCIPAL DISPLAY – Oxacillin 2 gram Vial Label

  • NDC 63323-812-01
    Oxacillin
    for Injection, USP
    2 grams per vial
    Buffered-For Intramuscular or Intravenous use
    Rx only
2 gram vial

SRC: NLM .

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