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Ocrelizumab Dosage

Generic name: ocrelizumab
Brand name: Ocrevus
Drug class: CD20 monoclonal antibodies

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Multiple sclerosis, relapsing forms

[600 mg IV q6mo]
Start: 300 mg IV x1, then 300 mg IV x1 after 2wk, then 600 mg IV x1 at 6mo after 1st dose; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; premed w/ corticosteroid 30min before and antihistamine 30-60min before each infusion; consider premed w/ antipyretic

Multiple sclerosis, primary progressive forms

[600 mg IV q6mo]
Start: 300 mg IV x1, then 300 mg IV x1 after 2wk, then 600 mg IV x1 at 6mo after 1st dose; Info: premed w/ corticosteroid 30min before and antihistamine 30-60min before each infusion; consider premed w/ antipyretic

Renal dosing

mild impairment: no adjustment; mod-severe impairment: not defined
HD/PD: not defined

Hepatic dosing

mild impairment: no adjustment; mod-severe impairment: not defined
SRC: NLM .

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