Ocaliva Dosage

Generic name: obeticholic acid
Drug class: Miscellaneous GI agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 5 mg, 10 mg

Primary biliary cholangitis

[5-10 mg PO qd]

Start: 5 mg PO qd x3mo, then may incr. to 10 mg PO qd if needed; Max: 10 mg/day; Info: for pts w/o cirrhosis or w/ compensated cirrhosis w/o evidence of portal HTN; may give w/ ursodiol; see pkg insert for severe pruritus management recommendations

Renal dosing

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

Hepatic dosing

[adjust dose amount, frequency]

Child-Pugh Class A: no adjustment; Child-Pugh Class B or C, decompensated cirrhosis, prior decompensation event, or compensated cirrhosis w/ evidence of portal HTN: contraindicated

SRC: NLM .