Nucynta ER Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: ER TAB: 50 mg, 100 mg, 150 mg, 200 mg, 250 mg
Pain, severe chronic
- [opioid-naive or opioid-nontolerant pts]
- Dose: individualize dose PO q12h; Start: 50 mg PO q12h, may incr. by 50 mg PO q12h q3 days; Max: 500 mg/24h; Info: use lowest effective dose, shortest effective tx duration; consider lower start dose in pts 65 yo and older; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
- [opioid-tolerant pts]
- Dose: individualize dose PO q12h; Start: individualize start dose based on current opioid intake, see pkg insert for conversion, may incr. by 50 mg PO q12h q3 days; Max: 500 mg/24h; Info: use lowest effective dose, shortest effective tx duration; consider lower start dose in pts 65 yo and older; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
Neuropathic pain, severe diabetic
- [opioid-naive or opioid-nontolerant pts]
- Dose: individualize dose PO q12h; Start: 50 mg PO q12h, may incr. by 50 mg PO q12h q3 days; Max: 500 mg/24h; Info: use lowest effective dose, shortest effective tx duration; consider lower start dose in pts 65 yo and older; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
- [opioid-tolerant pts]
- Dose: individualize dose PO q12h; Start: individualize start dose based on current opioid intake, see pkg insert for conversion, may incr. by 50 mg PO q12h q3 days; Max: 500 mg/24h; Info: use lowest effective dose, shortest effective tx duration; consider lower start dose in pts 65 yo and older; do not cut/crush/chew/dissolve tab; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
Renal dosing
- CrCl <30: avoid use
- HD/PD: not defined
Hepatic dosing
- Child-Pugh Class B: start 50 mg q24h, max 100 mg/day; Child-Pugh Class C: avoid use
SRC: NLM .