Nucala Dosage

Generic name: mepolizumab
Drug class: Interleukin inhibitors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ (auto-injector): 100 mg; INJ (pre-filled syringe): 100 mg per mL; INJ (vial): 100 mg per mL

Severe asthma, maintenance tx

[100 mg SC q4wk]
Info: for add-on tx in pts w/ eosinophilic phenotype; consider varicella vaccine before tx start if herpes zoster risk

Eosinophilic granulomatosis w/ polyangiitis

[300 mg SC q4wk]
Info: consider varicella vaccine before tx start if herpes zoster risk

Hypereosinophilic syndrome

[300 mg SC q4wk]
Info: for pts w/ dz for at least 6mo w/o identifiable non-hematologic secondary cause; consider varicella vaccine before tx start if herpes zoster risk

Chronic rhinosinusitis w/ nasal polyps, adjunct tx

[100 mg SC q4wk]
Info: consider varicella vaccine before tx start if herpes zoster risk

Renal dosing

CrCl >50: no adjustment; CrCl <50: not defined
HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .